Scientific output: SCK•CEN Radiobiology

Peer-reviewed article

  • Suetens S, Konings K, Moreels M, Quintens R, Verslegers M, Soors E, Tabury K, Grégoire V, Baatout S. Higher Initial DNA Damage and Persistent Cell Cycle Arrest after Carbon Ion Irradiation Compared to X-irradiation in Prostate and Colon Cancer Cells. In: Front Oncol, 13:6 (2016) 
  • Suetens A., Moreels M., Quintens R., Soors E., Buset J., Chiriotti S, Tabury K, Gregoire V, Baatout S.- Dose- and time-dependent gene expression alterations in prostate and colon cancer cells after in vitro exposure to carbon ion and X-irradiation.- In: Journal of Radiation Research, 56:1(2015), p. 11-21
  • Beck M., Rombouts C., Aerts A., Moreels M., Quintens R., Tabury K., Michaux A, Janssen A, Neefs M, Van Oostveldt P, De Vos WH, Baatout S.- Modulation of gene expression in endothelial cells in response to high LET nickel ion irradiation.- In: Int J Mol Med., 34:4(2014), p. 1124-1132
  • Suetens A., Moreels M., Quintens R., Chiriotti Alvarez S., Tabury K., Michaux A., e.a.- Carbon ion irradiation of the human prostate cancer cell line PC3: A whole genome microarray study.- In: International Journal of Oncology, 44:4(2014), p. 1056-1072.- ISSN 1019-6439

Oral Presentations

  • Moreels M. “Gene expression alterations to carbon ion and X-irradiation” ESTRO 35 Turin, Italy (April 29 – May 3rd, 2016) 
  • Konings K.- The impact of different radiation qualities on molecular and functional changes in cancer cells: role of hedgehog signaling.- Seminars in radiobiology.- Mol, Belgium, 5 October 2015.
  • Konings K.- Impact of different radiation qualities on molecular and functional changes in cancer cells: role of Hedgehog signaling.- Evaluation moment .- Leuven, Belgium, 10 July 2015.
  • Konings K.- Impact of different radiation qualities on molecular and functional changes in cancer cells: role of Hedgehog signaling.- Follow-up meeting with KU Leuven promotor.- Leuven, Belgium, 15 June 2015.
  • Konings K.- Impact of different radiation qualities on molecular and functional changes in cancer cells: role of Hedgehog signaling.- Meet and greet our new scientific researchers.- Mol, Belgium, 21 November 2014.
  • Quintens R., Suetens A., Macaeva E.- Cellular and molecular effects of different beam qualities on cancer and blood cells.- BHTC workshop "Hadrontherapy: from cell to patient".- Namur, Belgium, 23 May 2014.
  • Suetens A. Cellular and Molecular characterization of the effects of different beam qualities on in vitro cancer cell models.- PhD Days SCK•CEN.- Mol, Belgium, 24 April 2014
  • Suetens A. Dose-, time- and cell type dependent changes in expression of motility genes in cancer cells after exposure to low- and high-LET radiation.- Seminars IREC.- Woluwe, Belgium, 26 February 2014
  • Suetens A.- Fundamental research in the field of hadrontherapy.- SCK•CEN, Mol, Belgium, February 27, 2014.- (European Master in Radiation Biology). [International Course]
  • Moreels M.- Introduction to hadron therapy: biological and clinical aspects.- SCK•CEN, Mol, Belgium, February 26, 2014.- (European Master in Radiation Biology). [International Course]
  • Suetens A.- Dose-, time- and cell type dependent changes in expression of motility genes in cancer cells after exposure to low- and high-LET radiation.- Seminars IREC .- Woluwe, Belgium, February 26 2014.- [Presentation]
  • Suetens A.- Carbon Ion Irradiation of the Human Prostate Cancer Cell Line PC3:
    a Whole Genome Microarray Study.- Seminars in radiobiology.- Mol, Belgium, 14 October 2013.- [Presentation]
  • Suetens A.- Time-dependent changes in expression of motility genes in prostate cancer cells after exposure to low- and high-LET radiation.- Melodi Workshop 2013 .- Brussel, Belgium, 8-10 October 2013.- [Presentation]
  • Suetens A.- Carbon ion irradiation of the human prostate cancer cell line PC3: a whole genome microarray study.- IREC PhD day at UCL.- Woluwe, Belgium, 22 September 2013.- [Presentation]
  • Moreels M.- Time-dependent changes in expression of motility genes in prostate cancer cells after exposure to low- and high-LET radiation.- ERR 2013.- Dublin, Ireland, 1-5 September 2013.- [Presentation]
  • Moreels M., Davide M.- WP1 BioQuaRT.- LNS PAC meeting.- Catania, Italy, 19 July 2013.- [Presentation]
  • Moreels M.- Introduction to hadron therapy: biological and clinical aspects.- SCK•CEN, Mol, Belgium, February, 2013.- (Two-week course on radiation-induced effects with particular emphasis on genetics, development, teratology, cognition as well as space-related health issues). [International Course]
  • Suetens A.- Fundamental research in the field of hadrontherapy.- SCK•CEN; DOREMI, Mol, Belgium, February 27, 2013.- (European master in radiation biology). [International Course]
  • Joret M.- The Clinical Aspects of Prostate Cancer.- seminars in RDB.- Mol, Belgium, 18 January 2013.- [Presentation]
  • Baatout S.- Welcome words and presentation of the aims of the workshop.- 1st in vitro BHTC workshop.- Brussels, Belgium, 26-26 October 2012.- [Presentation]
  • Beck M., Rombouts C., Moreels M., Aerts A., Quintens R., Tabury K., e.a.- Modulation of gene expression of endothelial cells in response to high and low LET irradiation.- 1st BHTC in vitro workshop.- Brussel, Belgium, 25-25 October 2012.- [Presentation]
  • Moreels M.- Biological aspects of hadrontherapy.- 1st BHTC in vitro Workshop.- Brussels, Belgium, 25-25 October 2012.- [Presentation]
  • Suetens A.- Influence of carbon ion radiation on metastasis related genes in human prostate cancer cells.- 1st BHTC in vitro Workshop.- Brussels, Belgium, 25-25 October 2012.- [Presentation]
  • Moreels M.- Carbon ion irradiation suppresses metastasis related genes in prostate cancer cells.- The European Forum to discuss Nuclear Technology Issues, Opportunities
  • Suetens A.- Introduction to hadrontherapy – Models for in vitro and in vivo research.- Summer school RDB.- Mol, Belgium, 6-14 August 2012.- [Presentation]
  • Baatout S.- Lecture 1 Biology: Interaction of radiation with the matter.- Helmholtz Graduate School for Hadrons and Ion Research, Lecture Biophysics Week.- Laubach, Germany, 10-15 June 2012.- [Presentation]
  • Baatout S.- Lecture 2 Biology: Epidemiological studies and hereditary effects of radiation.- Helmholtz Graduate School for Hadrons and Ion Research, Lecture Biophysics Week.- laubach, Germany, 10-15 June 2012.- [Presentation]
  • Baatout S.- Lecture 3 biology: Radiation short- and long-term effects.- Helmholtz Zentrum München (HMGU) , Laubach, Germany, June 13, 2012.- (Helmholtz Graduate School for Hadrons and Ion Research, Lecture Biophysics Week). [International Course]
  • Baatout S.- Lecture 4 Biology: Radiation-induced cell death.- Helmholtz Zentrum München (HMGU), Laubach, Germany, June 14, 2012.- (Helmholtz Graduate School for Hadrons and Ion Research, Lecture Biophysics Week). [International Course]
  • Suetens A.- A contribution to the biological study of the response of prostate and colon cells to carbon ion irradiation.- Day of the PhD.- Mol, Belgium, 27 April 2012.- [Presentation]
  • Suetens A.- In vitro and in vivo models for hadrontherapy.- European Master in Radiobiology.- Mol, Belgium, 5-16 March 2012.- [Presentation]
  • Moreels M.- Introduction to hadron therapy: biological and clinical aspects.- SCK•CEN, Mol, Belgium, March, 2012.- (European Master in Radiobiology). [International Course]
  • Suetens A.- PhD status and perspectives. Review of Relative Biological Effectiveness (RBE).- Seminars in radiobiology.- Mol, Belgium, 27 February 2012.- [Presentation]
  • Moreels M.- Introduction to hadron therapy: biological and clinical aspects.- SCK•CEN, Mol, Belgium, February, 2011.- (European Master in Radiation Biology). [International Course]
  • Suetens A.- In vitro and in vivo models for hadrontherapy.- Eur MSc course in Radiation Biology.- Mol, Belgium, 14-25 February 2011.- [Presentation]
  • Suetens A.- A biological and dosimetric study of hadrontherapy on tumor and normal cells.- meet and greet EHS.- Mol, Belgium, 8-8 December 2010.- [Presentation]

Poster presentation

  • K. Konings, M. Moreels, A. Suetens, A. Gonnissen, S. Isebaert, K. Haustermans, S. Baatout. Effect of X-rays and carbon ions on cell survival and expression of Hh pathway genes in cancer cells. ESTRO 35 Turin, Italy (April 29 – May 3rd, 2016) 
  • Konings K., Moreels M., Isebaert S., Haustermans K., Baatout S.- The impact of different radiation qualities on molecular and functional changes in cancer cells: role of Hedgehog signaling.- Day of the PhD's.- Mol, Belgium, 29 October 2015Soors E., Suetens A., Dewilde S., Moreels M.- In vitro effecten van ioniserende straling op kankercellen.- Examen Masterstage, Master Biochemie, January 10, 2014
  • Suetens A., Moreels M., Tabury K., Quintens R., Michaux A., Chiriotti Alvarez S., e.a.- Dose-, time- and cell type- dependent changes in expression of motility genes in cancer cells after exposure to low- and high-LET radiation.- Annual BACR meeting.- Gent, Belgium, 1 February 2014.- [Poster]
  • Suetens A., Moreels M., Quintens R., Chiriotti Alvarez S., Tabury K., Michaux A., e.a.- A biological study of hadrontherapy: molecular changes in tumor cells.- PhD day SCK-CEN.- Mol, Belgium, 23 October 2013.- [Poster]
  • Marjan Moreels , Annelies Suetens, Kevin Tabury, Roel Quintens , Arlette Michaux , Emiliano d’Agostino, Vincent Grégoire , Sarah Baatout –Carbon ion irradiation induces strong effects at the level of gene expression in human prostate carcinoma cells compared to low-LET irradiation. HITSRS2013, Chiba, Japan 15-18 May 2013.- [Poster]
  • Suetens A., Moreels M., Tabury K., Quintens R., Michaux A., d’Agostino E., Grégoire V., Baatout S.-  Carbon ion irradiation suppresses metastasis related genes in human prostate carcinoma cells.- Physical Biology of Cancer.- Candiolo, Italy, 7-10 March 2013.- [Poster]
  • Suetens A., Moreels M., Quintens R., D'Agostino E., Tabury K., Moyer M., e.a.- Healthy tissue sensitivity after hadrontherapy.- MELODI-2012.- Helsinki, Finland, 12-14 September 2012.- [Poster]
  • Suetens A., Moreels M., Tabury K., D'Agostino E., Baatout S.- Biological effects induced by low-LET radiation in human prostate and colon carcinoma cell lines.- Radiation Science in the Netherlands 2nd symposium.- Noordwijkerhout, Netherlands, 19-20 April 2012.- [Poster]
  • Suetens A., Moreels M., Tabury K., D'Agostino E., Baatout S.- Biological effects induced by low-LET radiation in human prostate and colon carcinoma cell lines: Experimental basis for future experiments with carbon ions.- The Association of Radiation Research (ARR) Annual Conference .- Londen, United Kingdom, 25-27 June 2012.- [Poster]
  • Suetens A., Moreels M., D'Agostino E., Tabury K., Grégoire V., Baatout S.- A contribution to the biological study of the response of prostate and colon cells to carbon ion irradiation.- PhD day.- Mol, Belgium, 6 October 2011.- [Poster]
  • Suetens A., Moreels M., Tabury K., D'Agostino E., Baatout S.- Biological effects induced by low-LET radiation in human prostate and colon carcinoma cell lines: Experimental basis for future experiments with carbon ions.- NanoIBCT.- Caen, France, 2-6 October 2011.- [Poster]

PhD Thesis

  • Suetens A.- Cellular and molecular characterization of the effects of different beam qualities on in vitro cancer cell models.- Woluwé-Saint-Lambert, Belgium: Université catholique de Louvain-La-Neuve, 2015.- 270 p.- PhD thesis

In-Proceedings article

  • Annelies Suetens, Marjan Moreels, Kevin Tabury, Roel Quintens, Emiliano D’Agostino, Sarah Baatout, Frank Deconinck. Carbon ion irradiation suppresses metastasis related genes in human prostate carcinoma cells. ENC conference, Manchester, December 2012
  • D'Agostino E., Hartman T., Stenerlow B.- Dose distribution of a 38MeV/u carbon ions beam interacting with a plexiglass energy degrader: a Monte Carlo study.- In: Radiation Damage in Biomolecular Systems, Madrid, Spain, 30 June - 4 July 2010, Madrid, Spain, G. García Gómez-Tejedor, 2010

SCK•CEN reports

  • Soors E., Moreels M., Dewilde S., Suetens A.- In vitro effecten van ioniserende straling op kankercellen.- Antwerpen, Belgium: Universiteit Antwerpen, 2014.- 23 p.- (Universiteit Antwerpen)
  • Baatout S., Deconinck F., Lucas S., Moreels M.- 1st BHTC (Belgian Hadrontherapy Centre) in vitro Workshop.- Mol, Belgium: SCK•CEN, 2012.- 29 p.- (Book of Abstracts; BA-49)

Written projects to apply for beam time

  1. Proposal for a new experiment at GANIL (Caen, France): Biological Effects of Carbon Ions on human Prostate and Colon Cells for Hadrontherapy, January 2013.
  2. Proposal for a new experiment at INFN-LNS (Catania, Italy): WP1-BioQuaRT: Microdosimetric and radiobiological characterization of a carbon beam, March 2013